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This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 301. |
(a) Name a genetic RNA and a non-genetic RNA. (b) Differentiate between prokaryotic mRNA and eukaryotic mRNA on the basis of any one character. |
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Answer» (a) Genetic RNA - Double stranded RNA of mammalian reovirus Non-genetic RNA - Ribosomal RNA, messenger RNA or transfer RNA (b) Prokaryotic mRNA is short lived and hardly undergo any processing. In eukaryotes, the transcribed RNA (hn RNA) undergoes processing (capping, methylation and polyadenylation) to form comparatively stable mRNA. |
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| 302. |
The following is not a character of RNAA. RNA is unstable and degradableB. RNA mutates at faster rate than DNAC. RNA evolves slowlyD. RNA is catalytic/reactive |
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Answer» Correct Answer - C `**" "`Both DNA and RNA are able to mutate. `**" "`In fact, RNA being unstable, mutate at a faster rate. `**" "`Consequently, viruses having RNA genome and having shorter life span mutate and evolve faster. |
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| 303. |
`A+G=C+T` is applicable toA. rRNAB. tRNAC. mRNAD. DNA |
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Answer» Correct Answer - D `A+G=C+T` is applicable to DNA (doubl stranded). |
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| 304. |
Operon unit consists ofA. regulator, operator and repressive geneB. regulator, structural and operator geneC. regulator, structural, operator and promotor geneD. regulator, structural and promoter gene |
| Answer» Correct Answer - C | |
| 305. |
Episomes were discovered by Jacob and Wollman (1960). These representA. extrachromosomal segment that is temporarily attache with main nucleoidB. extrachromosomal genetic material independent of main necleoidC. virusesD. archaebacteria |
| Answer» Correct Answer - A | |
| 306. |
The human chromosomes with the highest and least number of genes in them are respectf vely :A. Chromosome 21 and YB. Chromosome 1 and XC. Chromosome 1 and YD. Chromosome X and Y |
| Answer» Correct Answer - C | |
| 307. |
House keeping genes areA. constitutive genesB. always in actionC. requried constantlyD. all of these |
| Answer» Correct Answer - D | |
| 308. |
Genes that trigger normal cells to cause cancer are calledA. house keeping constitutive genesB. silent genesC. oncogenesD. recessive genes |
| Answer» Correct Answer - C | |
| 309. |
Sum of all the genes is a population is calledA. genotypeB. gene poolC. gene factorD. genome |
| Answer» Correct Answer - B | |
| 310. |
If 50 heavy DNA `(N^(15))` molecules are replicated 2 times in `N^(14)` medium, what is obtained?A. genotypeB. gene poolC. gene factorD. none of the above |
| Answer» Correct Answer - A | |
| 311. |
Match the following in column I with column II and choose the correct combination A. A-2, B-3 , C-1 , D-4B. A-1, B-4, C-2, D-3C. A-3,B-1, C-4, D-2D. A-4, B-2,C-1, D-3 |
| Answer» Correct Answer - c | |
| 312. |
Automated - DNA sequencers are based on method developed byA. Erwin chargaffB. Maurice wilkinsC. Frederick sangerD. Francis crick |
| Answer» Correct Answer - C | |
| 313. |
Automated - DNA sequencers are based on method developed byA. Erwin ChargaffB. Maurice WilkinsC. Francis CrickD. Frederick Sanger |
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Answer» Correct Answer - D Automated - DNA sequencing is based or method developed by Frederick Sanger. |
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| 314. |
Automated DNA sequencers, work on the peinciple of the method developed byA. Erwin ChargaffB. Maurice WilkinsC. Frederick SangerD. Francis Crick |
| Answer» Correct Answer - c | |
| 315. |
If percentage of cytosine is 18 %, then percentage of thymine will beA. 0.32B. 0.64C. 0.36D. 0.23 |
| Answer» Correct Answer - a | |
| 316. |
Which one of the following pair is correctly matchedA. Frederick Griffith Discovered the phenomenon of transformationB. Linus Pauling Isolated the DNA for the first timeC. Francis Crick Proposed one gene one polypeptide hypothesisD. George Beadle Proposed the concept of inborn errors |
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Answer» Correct Answer - a a) In 1928, Frederick Griffith peformed transformation experimented by using Streptococcus pneumoniae. |
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| 317. |
Viroids differ from viruses in havingA. DNA molecules with protein coatB. DNA molecules without protein coatC. RNA molecules with protein coatD. RNA molecules without protein coat |
| Answer» Correct Answer - D | |
| 318. |
Select the incorrect matched pair.A. Initiation codons-AUG,GUGB. Stop codons-U A A , UAG, UGAC. Methionine- AUGD. Anticodons - mRNA |
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Answer» Correct Answer - d |
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| 319. |
The given figure shows lac operon and its functioning. Select the option which correctly labels A, B, X, Y and Z A. `{:(A,B,X,Y,Z),("Repressor","Inducer",beta-"galactosidase","Permease","Transacetylase"):}`B. `{:(A,B,X,Y,Z),("Repressor","Inducer","Permease",beta-"galactosidase","Transacetylase"):}`C. `{:(A,B,X,Y,Z),("Inducer","Repressor",beta-"galactosidase","Permease","Transacetylase"):}`D. `{:(A,B,X,Y,Z),("Inducer","Repressor",beta-"galactosidase","Transacetylase","Permease"):}` |
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Answer» Correct Answer - a |
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| 320. |
Identify the labels A, B, C and D in the given structure of tRNA and select the correct option. A. `{:(A,B,C,D),("Anticodon loop",TPsiC "loop","A A binding site","DHU loop"):}`B. `{:(A,B,C,D),("A A binding site",TPsiC "loop","Anticodon loop,"DHU loop"):}`C. `{:(A,B,C,D),("A A binding site",DHU "loop","Anticodon loop,TPsi "loop"):}`D. `{:(A,B,C,D),("A A binding site",DHU "loop",TPsiC"loop,Anticolon loop"):}` |
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Answer» Correct Answer - b |
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| 321. |
If the sequence of bases in DNA is GCTTAGGCAA then the sequence if bases in its transcript will beA. GCT TAG G C A AB. CGA A TC C GT TC. CGA A U C C G U UD. A A C G G A U U C G |
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Answer» Correct Answer - c (c) : mRNA strand is complementary to one of the DNA strands i.e., template strand . In RNA , uracil is present instead of thymine which is complementary to adenine. Cytosin and guanine are also complementary to each other. Hence, the sequence of bases in transcript would be CGAAUCCGUU. |
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| 322. |
Transcription unitA. starts with TATA boxB. starts with palindrome regions and ends with rho factorC. starts with promoter region and ends in terminator regionD. starts with C A A T region. |
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Answer» Correct Answer - c (c) : Transcription unit is the distance between sites of initiation and termination by RNA polymerase . It may include more than one gene. RNA polymerase produces transcription sequences. |
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| 323. |
Given diagram represents the components of a transcription unit. Select the correct answer regarding it . A. `{:(A,B,C,D),("Terminator ","Promoter","Template strand","Coding strand"):}`B. `{:(A,B,C,D),("Promoter ","Terminator ","Coding strand","Template strand"):}`C. `{:(A,B,C,D),("Promoter ","Terminator","Template strand","Coding strand"):}`D. `{:(A,B,C,D),("Terminator ","Promoter","Coding strand","Template strand"):}` |
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Answer» Correct Answer - c (c) |
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| 324. |
The ultimate biological unit which controls heredity, is called :A. GenomeB. GenotypeC. ChromosomeD. Gene |
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Answer» Correct Answer - D Ultimate biological unit which controls heredity is called gene. |
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| 325. |
DNA is a polymer of Or Which is the ultimate unit of DNA moleculeA. ProteinB. CarbohydrateC. RNAD. Nucleotides |
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Answer» Correct Answer - d d) DNA is the polymer of deoxyribonucleotides. Nucleic acid is made up of units of nucleotide. In a nucleotide, purine or pyrimidine nitrogenous base is joined by deoxyribose pentose sugar (D), which is further linked with Phosphate (P) group to form nucleotides. |
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| 326. |
Which one of the following palindromic base sequences in DNA can be easily cut at about the middle by some particular reatriction enzymeA. B. C. D. |
| Answer» Correct Answer - d | |
| 327. |
What is wrong about protein synthesis ?A. Only one strand of DNA acts as template for mRNA synthesisB. DNA polymerase mediates mRNA synthesisC. mRNA passes into cytoplasm and gets attached to 30S ribosomal subunitD. tRNA bring amino acids one by one |
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Answer» Correct Answer - B RNA polymerase mediates mRNA synthesis. |
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| 328. |
Choose the wrong statement in the process of protein synthesisA. After uncoiling of DNA moleucle, one strand acts as a tmeplete for the formation `m-RNA`B. In the presence of DNA polymerase enzyme the m -RNA is formed based on the triplet codesC. The m-RNA that leaves nucleus reaches cytoplasm and gets attached with 30S ribosomal subunitD. The amino acids are transfered from the intracellular amino acid pool to the active ribosomes by the t-RNA |
| Answer» Correct Answer - b | |
| 329. |
The point mutation A to G,C to T,C to G,T to A in DNA areA. transversion, transition, translocation, frame shift respectivelyB. transition, transition, transversion, transversion respectivelyC. transition onlyD. frame shift (gibbersish) metations only |
| Answer» Correct Answer - B | |
| 330. |
Transition mutation is due to replacement ofA. GC by TAB. AT by CGC. CG by GCD. AT by GC |
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Answer» Correct Answer - D Substitution (Replacement) : In substitution a nitrogen base is changed with another base. It is of two types - transition and tranversion. 1. Transition : Purine is replaced by purine `(A hArr G)` while pyrimidine is replaced by pyrimidine `(C hArr T, C hArr U)`. 2. Transversion : Purine is replaced by pyrimidine `(A rarr C)` while pyrimidine is replaced by purine `(C rarr A)`. e.g.: `SCA (GAG rarr GUG)`. A classical example of point mutation is a change of single base pair in the gene for beta globin chain that results in the change of amino acid residue glutamate to valine. It results into a diseased condition called as sickle cell anemia. |
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| 331. |
Temin worked on virusA. RhinovirusB. Dengue virusC. Herpes virusD. Retrovirus |
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Answer» Correct Answer - D Temin worked on retrovirus (Rous sarcoma virus). |
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| 332. |
RNA polymerase II is responsible for transcription ofA. rRNAB. hnRNAC. tRNAD. SnRNA |
| Answer» Correct Answer - B | |
| 333. |
Out of 64 condon, the number of condns with GGG isA. 1B. 2C. 4D. 6 |
| Answer» Correct Answer - a | |
| 334. |
Which is not correctly matchedA. Lipase - Hydrolysis of fatsB. Isomerases - Joinong of similar substrate and management of substrateC. Polymerase - Chain elongationD. DNA ligase - Breaks DNA strand into two segments |
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Answer» Correct Answer - d d) DNA ligase adjoins the nucleotides in DNA strand. |
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| 335. |
The deflection of pitch angle between two successive steps (rungs) of DNA isA. `72^(@)`B. `54^(@)`C. `36^(@)`D. `18^(@)` |
| Answer» Correct Answer - c | |
| 336. |
Commonly used vectors for human genome sequencing areA. T/A Cloning VectorsB. T-DNAC. BAC and YACD. Expression Vectors |
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Answer» Correct Answer - C `**" "`For sequencing, the total DNA from a cell is isolated and converted into random fragments of relatively smaller sizes (recall DNA is a very long polymer, and there are technical limitations in sequencing very long pieces of DNA) and cloned in suitable host using specialised vectors. `**" "`The cloning resulted into amplification of each piece of DNA fragment so that it subsequently could be sequenced with ease. `**" "`The commonly used hosts were bacteria and yeast, and the vectors were called as BAC (bacterial artificial chromosomes), and YAC (yeast artificial chromosomes). |
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| 337. |
Which one of the following is not a part of trasncription unit in DNAA. The inducerB. A terminatorC. A promoterD. The structural gene |
| Answer» Correct Answer - A | |
| 338. |
Which one of the following is not a part of trasncription unit in DNAA. A terminatorB. A promoterC. The structural geneD. The inducer |
| Answer» Correct Answer - D | |
| 339. |
Which one of the following is not a part of trasncription unit in DNAA. The inducerB. A termintorC. A promoterD. The sturctural gene |
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Answer» Correct Answer - a a) Transription unit consists of promoter, structural gene and terminator. |
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| 340. |
RNA interference involvesA. Synthesis of `c RNA` from RNA using reverse transcriptaseB. Silencing of specific `m RNA` due to complementry RNAC. Interference of RNA in synthesis of DNAD. Synthesis of `m RNA` from DNA |
| Answer» Correct Answer - b | |
| 341. |
Terinium is also called asA. Reverse trascriptionB. TranscriptionC. TranslationD. Replication |
| Answer» Correct Answer - a | |
| 342. |
Repressor protein is produced by :A. Repressor geneB. Structural geneC. Operator geneD. Regulartory gene |
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Answer» Correct Answer - d d) Regulator gene controls the activity of operator gene by producting repressor molecules or it codes for repressor protein (gene regulatory protein). |
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| 343. |
The following figure shows the process of A. Transcription and translationB. TranslationC. ReplicationD. Central dogma |
| Answer» Correct Answer - B | |
| 344. |
Find the correct match.A. UUA-ValineB. AUG-CysteineC. AAA-LysineD. CCC-Alanine |
| Answer» Correct Answer - C | |
| 345. |
Regulation of gene expression occus at the level ofA. transcriptionB. processin/splicingC. translationD. all of these. |
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Answer» Correct Answer - d |
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| 346. |
Match column I with column II and select the correct option from the given codes. `{:("Column I","Column II"),(A."Translation",(i)"Aminoacyl tRNA synthetase"),(B."Transcription",(ii)"Okazaki fragments"),(C."DNA replication",(iii)"RNA polymerase"):}`A. A-(ii),B-(i), C-(iii)B. A-(i),B-(iii), C-(ii)C. A-(iii),B-(i), C-(ii)D. A-(ii),B-(iii), C-(i) |
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Answer» Correct Answer - b |
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| 347. |
What is an anticodon ? |
| Answer» A base triplet at the recognition end of tRNA molecule. | |
| 348. |
Write the functions of RNA polymerase-I and RNA-polymerase-III. |
| Answer» RNA polymerases I and ID catalyse the transcription of r-RNA and t-RNA respectively. | |
| 349. |
Molecular basis of organ differentiation depends on the modulation in transcription byA. ribosomeB. transcription factorC. anticodnD. RNA polymerase |
| Answer» Correct Answer - B | |
| 350. |
The best HLA (Human Leucocyte Antigen) match for trans- plants in order to preference is:A. `"Parent" gt "sibling" gt "twin" gt "unrelated donor"`B. `"Sibling" gt "twin" gt "parent" gt "unrelated donor"`C. `"Twin" gt "sibling " gt "parent" gt "unrelated donor"`D. `"Twin" gt "unrelated donor" gt "parent" gt "sibling"` |
| Answer» Correct Answer - c | |