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This section includes InterviewSolutions, each offering curated multiple-choice questions to sharpen your knowledge and support exam preparation. Choose a topic below to get started.
| 201. |
Which of the following compound is not involved in Edman degradation?(a) Phenylisothiocyanate(b) CF3 COOH(c) FDNB(d) Phenylthiocarbonyl |
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Answer» Right answer is (c) FDNB For explanation I would say: FDNB is involved in Sanger’s method. |
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| 202. |
β-pleated sheets are the examples of _________(a) Primary structure(b) Secondary structure(c) Tertiary structure(d) Quaternary structure |
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Answer» Correct choice is (b) Secondary structure Explanation: Secondary structure of proteins is of two forms α-helix and β-pleated structures. |
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| 203. |
Calculate the ratio of the concentrations of acetate and acetic acid required in a buffer system of pH 5.30.(a) 3.2(b) 3.3(c) 3.4(d) 3.5 |
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Answer» The correct choice is (d) 3.5 For explanation: pH = pKa + log [acetate]/[acetic acid] log [acetate]/[acetic acid] = pH – pKa = 5.30 – 4.76 = 0.54 [acetate]/[acetic acid] = antilog 0.54 = 3.5. |
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| 204. |
The bond dissociation energy of hydrogen bonds in a water molecule is ______________(a) 470 kJ/mole(b) 470 J/mole(c) 23 kJ/mole(d) 23 J/mole |
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Answer» The correct answer is (c) 23 kJ/mole The explanation is: The energy required to break the hydrogen bonds (H-H) in water molecule is 23 kJ/mole. |
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| 205. |
Which of the following is false?(a) Lysozyme has S-S linkage(b) Ribonuclease has S-S linkage(c) Heme group in cytochrome c is covalently linked to the protein on two sides(d) Ribonuclease has SH-SH linkage |
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Answer» The correct answer is (d) Ribonuclease has SH-SH linkage Easiest explanation: Lysozyme and ribonuclease have disulfide linkages. |
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| 206. |
The bond dissociation energy of O-H bond in a water molecule is _____________(a) 23 kJ/mole(b) 470 kJ/mole(c) 470 J/mole(d) 23 J/mole |
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Answer» Right answer is (b) 470 kJ/mole Best explanation: The energy required to break O-H bond in a water molecule is more than that required for breaking hydrogen bond, which is 470 kJ/mole. |
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| 207. |
Which of the following is Edman reagent?(a) Phenylisothiocyanate(b) CF3 COOH(c) FDNB(d) Phenylthiocarbonyl |
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Answer» Correct option is (a) Phenylisothiocyanate For explanation: The Edman reagent, phenylisothiocyanate reacts with the amine group of the N-terminal amino acid. |
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| 208. |
Which of the following is a Sanger’s reagent?(a) 1-fluoro-2, 4-dinitrobenzene(b) 1-fluoro-2, 3-dinitrobenzene(c) 1-fluoro-2, 4-trinitrobenzene(d) 1-fluoro-2, 3-trinitrobenzene |
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Answer» The correct choice is (a) 1-fluoro-2, 4-dinitrobenzene For explanation I would say: To identify the amino-terminal amino acid residue, Sanger developed the reagent 1-fluoro-2, 4-dinitrobenzene (FDNB). |
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| 209. |
Tertiary conformation of proteins is maintained by 3 types of bonds namely ionic, hydrogen and __________(a) Sulfide(b) Disulfide(c) Covalent(d) Peptide |
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Answer» The correct choice is (b) Disulfide To elaborate: Ionic interactions, hydrogen and disulfide linkages stabilizes tertiary structure of a protein. |
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| 210. |
Which of the following about spontaneous folding is false?(a) It involves the initial formation of highly compact structure(b) It involves initial formation of a local secondary structure(c) It is essentially a random process(d) It may be defective in some human diseases |
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Answer» The correct choice is (c) It is essentially a random process The explanation: Protein folding is a spontaneous process aided by the hydrophobic interactions which is not random. |
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| 211. |
In 3° structure of proteins, folding and shaping is done by __________(a) Hydrophobic interactions(b) Polar interactions(c) Hydrogen bonding(d) None of the mentioned |
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Answer» The correct choice is (a) Hydrophobic interactions The explanation: Globular proteins have a tertiary structure with hydrophobic amino acid residues and a surface region of hydrophilic residues; these hydrophobic interactions are responsible for the folding and shaping of 3° structure of proteins. |
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| 212. |
Vision, olfaction and gustation employ _________(a) Serpentine receptors(b) Enzyme coupled receptors(c) Ligand gated receptors(d) Adhesion receptors |
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Answer» Right option is (a) Serpentine receptors The explanation: Serpentine receptors play an important role in rhodopsins, visual sense, olfaction and gustation. |
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| 213. |
Which of the following about Rb tumor suppressor protein is correct?(a) It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received(b) It is activated when phosphorylated by Cdk(c) It is a transcription factor(d) When a mitogenic signal is received, it binds the transcription factor E2F and thus stimulates the cell to enter S phase |
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Answer» Right option is (a) It binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received To explain I would say: Rb protein binds E2F transcription factor and prevents cell from entering S phase until a mitogenic signal is received. |
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| 214. |
Which of the following takes place due to phosphorylation of isocitrate dehydrogenase?(a) Inhibits the binding of citrate at active site(b) Degrades the enzyme(c) Enhances the substrate-binding affinity(d) No reaction |
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Answer» Right option is (a) Inhibits the binding of citrate at active site For explanation I would say: The electrostatic repulsion by the phosphoryl group inhibits the binding of citrate at active site. |
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| 215. |
Which of the following statements is not true about RNA?(a) Does not have a double stranded structure(b) Thymine is present(c) Does not obey Chargaff’s rule(d) The sugar contained in RNA is a ribose |
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Answer» The correct choice is (b) Thymine is present To explain: Thymine is present in DNA. |
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| 216. |
Which of the following could be coded by a tumor-supressor gene?(a) A protein that helps prevent progression through cell cycle(b) A protein that helps prevent apoptosis(c) A protein that codes for a DNA repair enzyme(d) A protein that forms part of a growth factor signaling pathway |
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Answer» The correct choice is (a) A protein that helps prevent progression through cell cycle Explanation: A protein that helps prevent progression through cell cycle could be coded by a tumor-supressor gene. |
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| 217. |
In the pentose phosphate pathway, the major products are ____________(a) Ribulose and NADPH(b) Ribulose and NADH(c) Ribulose and NAD^+(d) Ribulose and ATP |
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Answer» The correct answer is (a) Ribulose and NADPH To explain I would say: The products formed are pentose, ribulose and NADPH. |
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| 218. |
Which one out of the following enzymes acts in the pentose phosphate pathway?(a) Aldolase(b) Glycogen phosphorylase(c) Pyruvate kinase(d) 6-phosphogluconate dehydrogenase |
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Answer» The correct answer is (d) 6-phosphogluconate dehydrogenase The explanation is: The first reaction in pentose phosphate pathway is catalyzed by 6-phosphogluconate dehydrogenase. |
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| 219. |
The cellular organelles called “suicide bags” are (A) Lysosomes (B) Ribosomes (C) Nucleolus (D) Golgi’s bodies |
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Answer» The cellular organelles called “suicide bags” are Lysosomes. |
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| 220. |
The absorption of intact protein from the gut in the foetal and newborn animals takes place by (A) Pinocytosis (B) Passive diffusion (C) Simple diffusion (D) Active transport |
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Answer» A) Pinocytosis |
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| 221. |
In which phase of cell cycle is DNA replicated?(a) G1 phase(b) S phase(c) G2 phase(d) M phase |
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Answer» Right option is (b) S phase To explain: During the S phase, DNA replication takes place. |
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| 222. |
Mitochondrial DNA is (A) Circular double stranded (B) Circular single stranded (C) Linear double helix (D) None of these |
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Answer» Mitochondrial DNA is Circular double stranded. |
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| 223. |
The 2-component system drives bacterial chemotaxis by coupling autophosphoryaltion of which receptor to phosphorylation of respective regulatory protein?(a) His kinase(b) Adenylyl cyclase(c) Guanylyl cyclase(d) None |
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Answer» Right answer is (a) His kinase For explanation I would say: The 2-component system drives bacterial chemotaxis by coupling auto-phosphorylation of his kinase to phosphorylation of the respective regulatory protein. |
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| 224. |
Which of the following statement is correct about membrane cholesterol? (A) The hydroxyl group is located near the centre of the lipid layer (B) Most of the cholesterol is in the form of a cholesterol ester (C) The steroid nucleus form forms a rigid, planar structure(D) The hydrocarbon chain of cholesterol projects into the extracellular fluid |
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Answer» (C) The steroid nucleus form forms a rigid, planar structure |
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| 225. |
Which of the following codons is not a termination codon for protein synthesis?(a) UUU(b) UAG(c) UAA(d) UGA |
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Answer» The correct answer is (a) UUU To explain: After the ribosome reaches the codon UAG or UAA or UGA on m-RNA strand, protein synthesis is terminated. |
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| 226. |
The fatty acids can be transported into and out of mitochondria through (A) Active transport (B) Facilitated transfer (C) Non-facilitated transfer (D) None of these |
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Answer» (B) Facilitated transfer |
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| 227. |
Which of the following statements is true?(a) The template strand matches the sequence of the RNA transcript(b) The two strands of DNA run parallel to each other(c) G-C bonds are much more resistant to denaturation than A-T rich regions(d) The common form of DNA is left handed |
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Answer» The correct choice is (c) G-C bonds are much more resistant to denaturation than A-T rich regions Easy explanation: The two strands of DNA run antiparallel to each other. The common form of DNA is B-DNA which is right handed. |
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| 228. |
Which one is the heaviest particulate component of the cell? (A) Nucleus (B) Mitochondria (C) Cytoplasm (D) Golgi apparatus |
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Answer» (A) Nucleus |
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| 229. |
The most active site of protein synthesis is the (A) Nucleus (B) Ribosome (C) Mitochondrion (D) Cell sap |
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Answer» The most active site of protein synthesis is the Ribosome. |
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| 230. |
Which one is the largest particulate of the cytoplasm? (A) Lysosomes (B) Mitochondria (C) Golgi apparatus (D) Entoplasmic reticulum |
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Answer» (B) Mitochondria |
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| 231. |
Group of adjacent nucleotides are joined by ____________(a) Phosphodiester bond(b) Peptide bond(c) Ionic bond(d) Covalent bond |
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Answer» Right option is (a) Phosphodiester bond The explanation is: The phosphodiester linkage joins 3’ carbon atom of one sugar molecule and 5’ carbon atom of another carbon atom. |
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| 232. |
Which of the following is the correct equation?(a) CO2 + H2O H2CO3(b) CO2 + H2O HCO3(c) CO2 + H2O H3CO3(d) CO2 + H2O H2CO2 |
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Answer» Right choice is (a) CO2 + H2O H2CO3 To elaborate: The correct balanced equation is CO2 + H2O H2CO3. Carbondioxide reacts with water to give carbonic acid. |
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| 233. |
Repressor molecules bind to __________(a) Operator(b) Promoter(c) Enhancer(d) Hormone response element |
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Answer» Correct option is (a) Operator The best I can explain: An operator lies partially within the promoter, repressor binds to the DNA at operator region inhibiting the expression of genes. |
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| 234. |
The degradative Processess are categorized under the heading of (A) Anabolism (B) Catabolism (C) Metabolism (D) None of the above |
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Answer» (B) Catabolism |
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| 235. |
The average pH of Urine is (A) 7.0 (B) 6.0 (C) 8.0 (D) 0.0 |
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Answer» The average pH of Urine is 6.0. |
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| 236. |
Which of the following nucleotides is not present in DNA?(a) AMP(b) GMP(c) CMP(d) UMP |
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Answer» The correct choice is (d) UMP Best explanation: Uridine monophosphate is present in RNA. |
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| 237. |
Which of the following nucleotides is not present in RNA?(a) AMP(b) GMP(c) CMP(d) TMP |
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Answer» The correct option is (d) TMP For explanation I would say: Thymidine monophosphate is present in DNA. |
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| 238. |
Bulk transport across cell membrane is accomplished by (A) Phagocytosis (B) Pinocytosis (C) Extrusion (D) All of these |
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Answer» (D) All of these |
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| 239. |
Which of the following is located in the mitochondria? (A) Cytochrome oxidase (B) Succinate dehydrogenase (C) Dihydrolipoyl dehydrogenase (D) All of these |
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Answer» (D) All of these |
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| 240. |
The pH of blood is 7.4 when the ratio between H2CO3 and NaHCO3 is (A) 1 : 10 (B) 1 : 20 (C) 1 : 25 (C) 1 : 30 |
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Answer» The pH of blood is 7.4 when the ratio between H2CO3 and NaHCO3 is 1 : 20. |
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| 241. |
The exchange of material takes place (A) Only by diffusion (B) Only by active transport (C) Only by pinocytos is (D) All of these |
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Answer» (D) All of these |
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| 242. |
Arrangement of nucleotides in DNA can be seen by ____________(a) Ultracentrifuge(b) X-Ray crystallography(c) Light microscope(d) Electron microscope |
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Answer» The correct choice is (b) X-Ray crystallography For explanation I would say: It is a scientific method used to determine the arrangement of atoms of a crystalline solid in a three dimensional space. |
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| 243. |
Which of the following is energy independent?(a) Active transport(b) Primary active transport(c) Secondary active transport(d) Passive transport |
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Answer» Right answer is (d) Passive transport To explain: Active transport is ATP dependent. |
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| 244. |
The surface tension in intestinal lumen between fat droplets and aqueous medium is decreased by (A) Bile Salts (B) Bile acids (C) Conc. H2SO4 (D) Acetic acid |
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Answer» (A) Bile Salts |
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| 245. |
Which of the following is an example of heterodimeric protein?(a) Integrin(b) Antibodies(c) Receptor tyrosine kinase(d) G-protein coupled receptor |
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Answer» Correct choice is (a) Integrin Explanation: Antibodies, receptor tyrosine kinase and G-protein coupled receptor are homodimeric. |
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| 246. |
Which of the following arrangement based on the increasing order of motion is correct?(a) Uncatalysed transverse motion, transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion(b) Uncatalysed lateral diffusion, uncatalysed transverse motion, transverse diffusion catalyzed by flippase(c) Uncatalysed transverse motion, uncatalysed lateral diffusion, transverse diffusion catalyzed by flippase(d) Transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion, uncatalysed transverse motion |
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Answer» The correct option is (a) Uncatalysed transverse motion, transverse diffusion catalyzed by flippase, uncatalysed lateral diffusion Best explanation: Uncatalysed transverse motion (slow), transverse diffusion catalyzed by flippase (fast), uncatalysed lateral diffusion (very fast). |
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| 247. |
The phenomenon of osmosis is opposite to that of (A) Diffusion (B) Effusion (C) Affusion (D) Coagulation |
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Answer» The phenomenon of osmosis is opposite to that of Diffusion. |
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| 248. |
The ability of the cell membrane to act as a selective barrier depends upon (A) The lipid composition of the membrane (B) The pores which allows small molecules (C) The special mediated transport systems (D) All of these |
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Answer» (D) All of these |
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| 249. |
Trans bilayer diffusion is also called ____________(a) Facilitated diffusion(b) Lateral diffusion(c) Flip flop(d) Simple diffusion |
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Answer» Correct answer is (c) Flip flop Easiest explanation: Trans bilayer diffusion is also called “Flip flop”. |
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| 250. |
Carrier protein can (A) Transport only one substance (B) Transport more than one substance (C) Exchange one substance to another (D) Perform all of these functions |
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Answer» Carrier protein can Perform all of these functions . |
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