Which will be the correct option for the marked place?(a) Acetylcholine(b) Gastrin(c) Histamine(d) Hydrogen ionsThis question was addressed to me during an online interview.Asked question is from Pharmacotherapy of Peptic Ulcer in chapter Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology

Which will be the correct option for the marked place?(a) Acetylcholin

1.	Which will be the correct option for the marked place?(a) Acetylcholine(b) Gastrin(c) Histamine(d) Hydrogen ionsThis question was addressed to me during an online interview.Asked question is from Pharmacotherapy of Peptic Ulcer in chapter Histamine, Bradykinin and their Antagonists, Pharmacotherapy of Gastric Ulcer, Peptic Ulcer of Drug Biotechnology
Answer» The correct choice is (a) Acetylcholine Explanation: Cholinergic neuron secretes acetylcholine that through circulation goes and bind to the muscarinic receptor in the parietal cell secrete ACID into the gastric lumen. Enterochromaffin-like CELLS secrete histamine which again goes and binds to the H2 receptor and through the cAMP pathway helps the parietal cell to secrete acid. GASTRIN secreted by Antral G cell is the hormonal control of acid secretion by the parietal cell. Gastrin, Histamine, and acetylcholine switch on the proton PUMP thus pumping H+ ions to produce acid in the gastric lumen.

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