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Write short note on allosteric enzymes |
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Answer» Allosteric enzymes are enzymes that change their CONFORMATIONAL ensemble UPON binding of an effector, which results in an apparent change in binding affinity at a different ligand binding site. This "ACTION at a distance" through binding of one ligand affecting the binding of another at a distinctly different site, is the essence of the allosteric concept.Allostery plays a crucial role in many fundamental biological processes, including but not limited to cell SIGNALING and the regulation of metabolism. Allosteric enzymes need not be oligomers as previously THOUGHT,[1] and in fact many systems have demonstrated allostery within single enzymes.[2] In biochemistry, allosteric regulation (or allosteric control) is the regulation of a protein by binding an effector molecule at a site other than the enzyme's active site. |
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