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write notes on E1;E2 and E'cB reactions with their stereochemistry |
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Answer» E1cB Mechanism E1cB mechanism (E-elimination, 1cB-first order with respect to conjugate base) is one of the three limiting mechanisms of1,2-elimination. It is a two-step mechanism. Step 1: *Only theleaving groupand one beta hydrogen are shown for clarity. Step 2: Step two is first order and its reactant is the conjugate base of the substrate, hence the notation 1cB. A 1,2-eliminationoccurringvia E1cB mechanism is called and E1cB reaction. Stand-alone E1cB reactions are not common, and they have a complex rate law, meaning that the rate-limiting step is the second step. However, in the most common E1cB reactions, the base is ‾OH and thesolventis water, in which case the rate law simplifies to rate = k[substrate][base] |
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