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Write brief sketch of pharmaceutical analysis​

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Answer:

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Explanation:

1. Pharmaceutical Analysis

2. Pharmaceutical analysis Pharmaceutical Analysis may be defined as the application of analytical procedures used to determine the purity, safety and quality of drugs and chemicals This course has access to the full range of  TITRATION method  SPECTROSCOPIC technique  Chromatographic method  Spectrophotometry etc.

3. Titration method Aqueous acid base titration: An aqueous acid–base titration is the determination of the concentration of an acid or base by exactly neutralizing the acid or base with an acid or base of known concentration. This allows for quantitative analysis of the concentration of an unknown acid or base solution. Aqueous acid–base titrations can also be used to find PERCENT purity of chemicals. Non aqueous acid base titration: Non aqueous titration is the titration of substances dissolved in solvents other than water. it provides a solvent in which organic compounds are soluble. The most commonly used procedure in this titration of organic bases with perchloric acid in anhydrous acetic acid. It is the most common titrimetric procedure used in pharmacopoeial assays and is suitable for the titration of very weak acids and very weak bases

4. Titration method Redox titration: A redox titration is a type of titration based on a redox reaction between the analyte and titrant. concentration of certain chemicals in pharmaceutical compounds can be determined through redox titration. Complexometric titration:Complexometric titration is a form of volumetric analysis in which the formation of a colored complex is used to indicate the end point of a titration. particularly useful for the determination of a mixture of different metal ions in solution

5. Potentiometric titration • Potentiometric titration is a technique similar to direct tritration of a redox reaction. It is a useful means of characterizing an acid. No indicator is used; instead the potential is measured across the analyte, typically an electrolyte solution.

6.  Amperometric titration: Refers to a class of titrations in which the equivalence point is determined through measurement of the electric current produced by the titration reaction. It is a form of quantitative analysis.  Aquametry : Aquametry in analytical chemistry refer to analytical processes to measure the water present in materials. Use : The methods widely used in aquametry encompasses Karl Fischer titration, distillation, chromatography etc.

7.  Refractometry is the method of measuring substances' refractive index (ONE of their fundamental physical properties) in order to, for example, assess their composition or purity.  Polarimetry is a sensitive, nondestructive technique for measuring the optical activity exhibited by inorganic and organic compounds.  Nephelometry is a technique used in immunology to determine the levels of several blood plasma proteins.

8. Spectroscopy Method Introduction to Visible & Ultraviolet Spectroscopy: Spectroscopy is the science which deals with the interaction between a matter (atom/molecule) and an electromagnetic radiation. Ultraviolet and visible spectroscopy is a type of absorption spectroscopy that uses the ultraviolet and visible parts of the electromagnetic spectrum.

9. Chromatography Chromatographic Methods: Chromatography is usually a technique for separating and / or identifying the components in a mixture. It is powerful method in industry. Some major types of chromatography:  Paper chromatography  Gas chromatography  Liquid chromatography  High performance liquid chromatography  Gel filtration chromatography

10. HPLC High Performance Liquid Chromatography: High performance liquid chromatography (HPLC) is a very EFFICIENT separation technique, that is, it yields excellent separation in a very short period of time. HPLC is a form of column chromatography. Its frequently used in biochemistry and analytical chemistry to separate component mixture.

11. Flurometry: An analytic method for detecting fluorescent compound using a beam of ultraviolet light that excites the compounds and causes them to emit visible light.

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