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Why only some b cell respond during immune response to pathogen?

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Answer:

The IMMUNE system is very complex. Part of the system RESPONDS to antigens found on the outside of pathogens or body cells. This is the humoral response and it is brought about MAINLY by the B lymphocytes. On the other hand, the cell-mediated system responds to body cells that have changed in some WAY – for example cells infected by VIRUSES, or cells such as cancer cells that have a mutation. It is brought about mainly by the T lymphocytes.

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