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Which polypeptide of cholera enterotoxin is nontoxic but immunogenic?(a) A1(b) A2(c) B(d) B1I had been asked this question by my college director while I was bunking the class.My question comes from Immunological Preparations in chapter Immunological Preparations of Drug Biotechnology

Answer»

Correct answer is (c) B

The explanation is: Cholera enterotoxin (PRODUCED by Vibrio cholerae) consists of three polypeptides: A1, A2 and B polypeptides. The A polypeptides are TOXIC, while the B polypeptide is nontoxic but immunogenic. THUS, we can use the B polypeptide for the MANUFACTURE of vaccines.



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