Which of the following does not describe local alignment algorithm?(a) Score can be negative(b) Negative score is set to 0(c) First row and first column are set to 0 in initialization step(d) In traceback step, beginning is with the highest score, it ends when 0 is encounteredThis question was addressed to me in an international level competition.This intriguing question comes from Local Sequence Alignment topic in portion Sequence Alignment of Bioinformatics

Which of the following does not describe local alignment algorithm?(a)

1.	Which of the following does not describe local alignment algorithm?(a) Score can be negative(b) Negative score is set to 0(c) First row and first column are set to 0 in initialization step(d) In traceback step, beginning is with the highest score, it ends when 0 is encounteredThis question was addressed to me in an international level competition.This intriguing question comes from Local Sequence Alignment topic in portion Sequence Alignment of Bioinformatics
Answer» Correct CHOICE is (a) Score can be negative For explanation I would say: Score can be negative. When any element has a score lower than zero, it means that the sequences up to this position have no SIMILARITIES; this element will then be set to zero to eliminate influence from PREVIOUS ALIGNMENT. In this way, calculation can continue to find alignment in any position AFTERWARD.

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