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Which antibody can cross placenta? |
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Answer» tion:Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that provides protection to the infant while his/her humoral response is INEFFICIENT. IgG is the only antibody CLASS that significantly crosses the human placenta. This crossing is mediated by FcRn expressed on syncytiotrophoblast cells. There is evidence that IgG transfer DEPENDS on the following: (i) maternal levels of total IgG and specific antibodies, (II) gestational age, (iii) placental integrity, (iv) IgG SUBCLASS, and (v) nature of antigen, being more intense for thymus-dependent ones. hope it helps you mate.......... |
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