What is pacman model ? in genetics

1.	What is pacman model ? in genetics
Answer» Answer: The RNA-induced SILENCING COMPLEX component Argonaute2 and orthologues of LSm4 and Xrn1 (Pacman) associated with 5'-3' mRNA DEGRADATION localize to some GWBs [1]. During early embryonic syncytial nuclear divisions, PCM transcripts are homogenously distributed. pcm mRNA is expressed abundantly and ubiquitously throughout the embryo during gastrulation, with high levels in the GERM band and head structures [2]. A Kin I-dependent Pacman-flux mechanism for anaphase A [3]. The Pacman model posits that chromatids induce the depolymerization of microtubule plus-ends embedded in kinetochores, thereby 'chewing' their way poleward [3].

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Answer:

The RNA-induced SILENCING COMPLEX component Argonaute2 and orthologues of LSm4 and Xrn1 (Pacman) associated with 5'-3' mRNA DEGRADATION localize to some GWBs [1].

During early embryonic syncytial nuclear divisions, PCM transcripts are homogenously distributed. pcm mRNA is expressed abundantly and ubiquitously throughout the embryo during gastrulation, with high levels in the GERM band and head structures [2].

A Kin I-dependent Pacman-flux mechanism for anaphase A [3].

The Pacman model posits that chromatids induce the depolymerization of microtubule plus-ends embedded in kinetochores, thereby 'chewing' their way poleward [3].

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