What are the causes of Down’s syndrome?

1.	What are the causes of Down’s syndrome?
Answer» 1. Down’s syndrome is caused due to aneuploidy. 2. Aneuploidy is due to non-disjunction of chromosome at the time of gamete formation during meiosis. Due to nondisjunction, chromosomes fail to separate. 3. In addition to a homologous pair of 21st chromosome there is an extra 21st, therefore it is called trisomy (2n + 1) of 21st chromosome.

Answer»

1. Down’s syndrome is caused due to aneuploidy.

2. Aneuploidy is due to non-disjunction of chromosome at the time of gamete formation during meiosis. Due to nondisjunction, chromosomes fail to separate.

3. In addition to a homologous pair of 21st chromosome there is an extra 21st, therefore it is called trisomy (2n + 1) of 21st chromosome.

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What are the causes of Down’s syndrome?

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