The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?(a) 625 mg/ml(b) 625 l(c) 625 ml(d) 0.0016 mg/mlThe question was posed to me in an interview for job.Enquiry is from One & Two Compartment Open Model topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology

The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.

1.	The i.v. bolus dosage is 500mg and the plasma drug concentration is 0.8 mg/ml. What should be the volume of distribution?(a) 625 mg/ml(b) 625 l(c) 625 ml(d) 0.0016 mg/mlThe question was posed to me in an interview for job.Enquiry is from One & Two Compartment Open Model topic in chapter Compartment Modelling, Non Linear Pharmacokinetics, Bioavailability and Bioequivalence of Drug Biotechnology
Answer» RIGHT choice is (C) 625 ml Easiest explanation: The apparent volume of DISTRIBUTION VD is GIVEN by Amount of drug in the body (X) / plasma drug concentration (C). Vd is expressed in liters or milliliters. Thus 500/0.8=625.

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