My 250gb SSD was running out of space , so I purchased a 500Gb SSD. I connected it up and ran Macruim reflect I selected the correct option for resizing to a larger disc size, it cloned the new 500GB as a 250GB. As you can see from the picture attachment my main drive is E and my boot is drive C. I cannot change the drive letter of C to any other drive letter as it states that the drive is needed to boot. It seems to me the boot is on drive C and everything else is on drive E. If I try to clone E to C and start all over again it asked if I want to proceed as windows PE, if I click on this, then after the next dialogue box it states that it cannot start from PE. Where do I go from here?Depends on how you want the new drive...if you want the full 500G i would re-do the clone as is...you can then allocate and merge the rest of the drive into 1 drive...
Also it appears you still have both HDD's attached...can you clarify this ?Hi
You will need to be running Macruim reflect from a CD or pen drive to do this...
First I would clone the first partition of your Drive 1 to somewhere like a pen drive. You will loose all the data on the pen drive. Drive 1 is your 250GB SSD.

Then clone back the first partition of Drive 0 the 500GB SSD this is the boot partition from the original 250 gb drive.

Disconnect the 500 GB SSD and check the 250 GB drive is BOOTING and loading windows if it does then you are back at the beginning before you STARTED copying the drive. If not then you will need to do a windows repair install.

Now reconnect the 500gb to the sata cable you were using for the 250 above this will make the 500 drive 1

Connect your 250 GB SSD as Drive 0.

Start Macruim reflect Now tick the box to the left of the 250GB selecting to copy the whole drive in the options you can select RESIZE or do the resize after the copy. Good idea to check the 500GB boots before doing the resize. if it boots ok then job done.