I've been having this problem recently while after my PC being on for an extended period of time (1 hour 30 mins or less) all my USB ports completely shut off. I can see when its coming as random USB ports turn off for about 3 secs and turn back on and eventually turn off all together and have to be unplugged and re-plugged this can happen to my mouse keyboard and other USB devices, lastly after the problems BUILD up my PC hits a climax and all my ports shut off all together. When this happens no unplugging and re-plugging will get the USB devices to work and my only option is to shut down my PC via the external off button. I have tried numerous times to fix this problem researching other sources and doing things such as disallowing usb's to shut of to save power, RESETTING bios, de-dusting my computer, turning on power saver, using different keyboards and mice, and many other software tweaks. Nothing works.

I'm at a loss and i have no idea if this is a software or a hardware problem, if its a power issue or a heat issue? I would love some opinions and some help. At the moment my PC is unusable and this problem has caused me to lose work as I could not save and made playing games impossible. If you need more information i would be happy to provide it, Thanks.

Specs-

CPU: i5-2400 CPU 3.10GHz

Operating system: Windows 10

Graphics card: GTX 1050ti

RAM: 8GB

Motherboard: GIGABYTE GA-H61M-S2PVHi

Sorry this is a very odd problem so a few further details might help.

Does the computer have the front USB ports installed and are you using any of these or is it just the back ports being used.
What power supply is installed and how old is it ?
Is it one usb device you use which causes this like a force feed back joystick as an example?

Hey I would be happy to elaborate.

1. The front USB ports are installed and I have my wifi ADAPTER and my HEADSET plugged into them.

2. My power supply is the TR2 RX-550PP and its a second hand part that I have had for maybe 3 years now

3. I'm not sure if its one device that causes this problem as I need them all plugged in to operate my computer

Hope this helps.Thinking more about the problem. The power supply seems ok so not the cause. Did this start when you installed the GTX 1050ti video card ?
If so you will may need the latest bios update.
If you are going to update the bios you must get the motherboard Revision. There was 5 revisions of your motherboard with  different bios versions for each revision. This problem didn't happen when I installed the 1050ti
I've had the 1050ti in for a while now and this problem has only started to happen recently
Hi, still trying to work out why this would be happening.

Can you download a program called speccy from here  https://www.ccleaner.com/speccy/download
After the program finishes running you can select file, publish report and copy the link given here.

Please only copy the link NOT the pages of the report.   
Speccy has problems and doesn't allow me to send the link, I've looked online its an overall problem with their application.

I could send you a snipping tool of the summery page?
Sorry, yes you are right the servers down again for speccy. I really need to whole report which can be 20 or 30 pages which is a bit much to post here. not just the summary page.Ok since speccy doesn't work is there any other way i could help you get my specs?Hi again,
As it is a usb problem there is a Microsoft program called usb view
https://softfamous.com/usbview/
This will tell you about the usb devices and ports check for any errors.
I wasn't going to suggest until i could see the speccy report but as it's not working i would run
https://www.afterdawn.com/software/system_tools/registry_tools/usb_oblivion.cfm
This is a usb cleanup tool, if you run it and delete all the usb devices and re detect the current ones. It may fix it .