1.

Sickle cell anemia in humans is a result of point mutation. Explain.

Answer»

Point mutation occurs due to change in a single base pair of DNA. It occurs due to defect caused by the single base substitution at the sixth condon of the beta chain of haemoglobin from GAG to GUG. 

This causes substitution of glutamic acid by valine. The defective haemoglobin molecule undergoes polymerization under low oxygen tension causing sickle- shaped red blood cells.



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