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Partial protection by 18 glycrrhetinic acid against cisplatin induced oxidative intestinal damage in wistar rats: possible role of nfkb and caspases. Pharmacological reports. |
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Answer» e is your answerCisplatin (CP) is a potent chemotherapeutic AGENT commonly USED for the treatment of various malignancies. It has varied UNDESIRABLE effects such as nephrotoxicity, intestinal toxicity which limit its wide and extensive clinical usage. 18β-Glycyrrhetinic acid (GA) is a pentacyclic triterpenoid DERIVATIVE, obtained from the HERB liquorice having pharmacological properties such as anti-inflammatory, hepatoprotective and antioxidant. The present study was designed to investigate in vivo efficacy of GA against CP induced small intestinal toxicity |
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