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Oxidative stress and vascular endothelial are recognized as important contributing factors in the pathogenesis of ad and dementia of vascular origin |
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Answer» The most accepted hypothesis proposes that deposition of INSOLUBLE amyloid β protein (Aβ) fragments causes the neurodegeneration in AD [5]. Aβ is thought to contribute to the ACCUMULATION of reactive OXYGEN species (ROS) resulting in oxidative stress, neuronal DAMAGE and cognitive decline |
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