1.

Outline the stages of carcinogenesis

Answer»

1st STAGE- Initiation

Rapid onset
Irreversible DNA damage
Modification of the biological potency of the affected cell

2nd stage- Promotion
Slow development (latency period: 5-30 years!)
Reversible
Non-additive

3rd stage- transformation
Further mutations
Conversion of a pre-neoplastic cell into a cell with malignant phenotype (UNCONTROLLED GROWTH, genetic instability)
Inheritance of damaged genetic MATERIAL to daughter cells



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