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Answer» 1st STAGE- Initiation
Rapid onset Irreversible DNA damage Modification of the biological potency of the affected cell
2nd stage- Promotion Slow development (latency period: 5-30 years!) Reversible Non-additive
3rd stage- transformation Further mutations Conversion of a pre-neoplastic cell into a cell with malignant phenotype (UNCONTROLLED GROWTH, genetic instability) Inheritance of damaged genetic MATERIAL to daughter cells
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