On what basis the dose interval is calculated?(a) Active drug concentration in the formulation(b) Half-life of the drug(c) Duration of the disease(d) Age of the patientThe question was posed to me in quiz.I need to ask this question from Pharmacokinetic Principles Applications topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology

On what basis the dose interval is calculated?(a) Active drug concentr

1.	On what basis the dose interval is calculated?(a) Active drug concentration in the formulation(b) Half-life of the drug(c) Duration of the disease(d) Age of the patientThe question was posed to me in quiz.I need to ask this question from Pharmacokinetic Principles Applications topic in portion Applications of Pharmacokinetic Principles, Diuretics, Drug Concentration and Pharmacologic Response of Drug Biotechnology
Answer» Correct answer is (b) Half-life of the drug To ELABORATE: Any dose frequency is being calculated on the BASIS of half-life of the drug. If the interval is increased without changing the dose, Cmax, Cmin, Cav decreases but the ratio of Cmax/Cmin increases. Opposite can be observed if DOSING interval is REDUCED frequency increased. It can also result in ACCUMULATION and toxicity.

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