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Neurochemical assessment and behavioral role of tuberofundibular peptide-39 in acute restraint stress induced depression in rats, |
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Answer» nfundibular peptide of 39 (TIP39) is a potent agonist to the parathyroid hormone 2 receptor (PTH2R) abundantly expressed in brain. The current study focused to evaluate the role of TIP39 in acute restraint stress (ARS)-induced depression model.Methods: Rats were EXPOSED to ARS for 2 h to establish the depression and then subjected to open field and forced SWIM test (OFT and FST). TIP39 (1 and 10 nmol/rat) and HYWH (1 nmol/rat) are a PTH2R antagonist which was infused through intracerebroventricular route. Diazepam (2 mg/kg, i.p) was utilized as REFERENCE standard. |
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