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Multigenerational undernutrition increases susceptibility to obesity and diabetes that is not reversed after dietary recuperation |
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Answer» in developing countries have faced multigenerational undernutrition and are currently undergoing major lifestyle changes, contributing to an epidemic of METABOLIC diseases, though the underlying mechanisms remain unclear. Using a Wistar rat model of undernutrition over 50 generations, we show that Undernourished rats exhibit low birth-weight, high VISCERAL adiposity (DXA/MRI), and insulin resistance (hyperinsulinemic-euglycemic clamps), compared to age-/gender-matched control rats. Undernourished rats also have HIGHER circulating insulin, homocysteine, endotoxin and leptin levels, lower adiponectin, VITAMIN B12 and folate levels, and an 8-fold increased SUSCEPTIBILITY to Streptozotocin-induced diabetes compared to control rats. Importantly, these metabolic abnormalities are not reversed after two generations of unrestricted access to commercial chow (nutrient recuperation). |
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