1.

Describe the packaging of DNA helix in a prokaryotic cell and an eukaryotic nucleus.

Answer»

Packaging of DNA 

Packaging of DNA in eukaryotes 

• The proteins associated with DNA are of two types—basic proteins (histone and protamine) and acidic non-histone chromosomal (NHC) proteins. 

• The negatively charged DNA molecule wraps around the positively charged histone proteins to form a structure called nucleosome. 

• The nucleosome core is made up of four types of histone proteins—H2A, H2B, H3 and H4— occurring in pairs. 

• 200 bp of DNA helix wrap around the nucleosome by 1¾ turns, plugged by H1 histone protein. 

• Repeating units of nucleosomes form the chromatin in nucleus, which is a thread-like structure. 

• The chromatin is packed to form a solenoid structure of 30 nm diametre.



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