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Clinical significance of bioequivalence studies

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METHODS To address this issue, we DECIDED to focus on publications REPORTING oral bioavailability results in one clinical pharmacology journal, namely, Clinical Pharmacology & Therapeutics. If this initial investigation were positive, subsequent research could involve a more complete examination of the literature. Data collection. All issues of Clinical Pharmacology & Therapeutics over a 25-year period, or from January 1970 through DECEMBER 1994, were examined. Articles that reported oral bioavailability data were …

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